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The clinical science
supporting Nuvane.

Combines peptide innovation and proven actives, backed by clinical studies, for visibly firmer, smoother, more radiant skin.

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NEXT-GENERATION PEPTIDE TECHNOLOGY

Reverse cellular aging.
See results in four weeks.

SenoP3™ is our clinically proven triple-peptide complex. It penetrates deep into the skin to target aging at the cellular level, visibly reducing fine lines and rebuilding firmness from within. In an IRB-approved clinical trial, users saw noticeable improvement in the reversal of signs of aging in as little as 4 weeks, with continued improvement through 12 weeks of use.

  • 30+ Years of research

    Laboratory innovation and clinical expertise.
  • 80+ Proven ingredients

    Clinically proven actives backed by research.
  • 500+ Clinical studies

    Proving the anti-aging effects of our ingredients.
  • 24/7 Expert Support

    Dermatological guidance available around the clock

12-week IRB-approved clinical study

Clinically proven to reverse aging

Real subjects, 12 weeks, no retouching.

AFTER
BEFORE

IMPROVEMENTS OBSERVED

REDUCED LINES
SMOOTHER TEXTURE
EVEN TONE
AFTER
BEFORE

IMPROVEMENTS OBSERVED

SOFTER FOLDS
SMOOTHER SKIN
REFINED TEXTURE
AFTER
BEFORE

IMPROVEMENTS OBSERVED

FIRMER SKIN
SOFTENED LINES
BETTER ELASTICITY
AFTER
BEFORE

IMPROVEMENTS OBSERVED

EVEN TONE
BRIGHTER COMPLEXION
FIRMER CONTOURS
AFTER
BEFORE

IMPROVEMENTS OBSERVED

SMOOTHER TEXTURE
LESS CREASING
TIGHTER SKIN

In our 12-week, IRB-approved clinical study, subjects recorded visible reversal across every measure of aging — smoother texture, softened expression lines and firmer, lifted skin.

All results reached statistical significance (P<0.001).

Source: Nuvane SenoP3™ IRB-approved Clinical Study (submitted to publication). Self-reported visible & tactile improvement at Week 12 (n=38 per-protocol); all results P<0.001.

3D Surface Topography

Results you can see — and we can measure.

Most skincare brands ask you to take their word. We imaged our subjects’ skin in 3 dimensions at Baseline, Week 4 and Week 12, and measured the change in wrinkle depth, feature count and volume — down to the micron.

Forehead wrinkles baseline 3D scan
Baseline
Forehead wrinkles week 4 3D scan
Week 4

Forehead wrinkles, visibly smoothed.

3D PRIMOS analysis (subject S002) showed a 55.8% reduction in depth volume at Week 4, sustained at 25.4% through Week 12 — with visibly shorter, thinner, more fragmented wrinkle traces on CBC-Depth colour mapping.

  • 92.1% Smoother, more refined texture
  • 86.8% Relaxed expression lines
  • 84.2% Firmer, tighter, lifted skin
Crow's feet baseline 3D scan
Baseline
Crow's feet week 12 3D scan
Week 12

Crow’s feet, visibly reduced.

3D topography of periorbital wrinkles (subject S015) showed a progressive 24.4% reduction in wrinkle depth volume by Week 12 (11.91 → 10.46 → 9.06 mm³). Wrinkle features fell from 26 to 10, and maximum depth from 0.390 to 0.300 mm.

  • 24.4% Depth volume reduction
  • -62% Wrinkle features (26→10)
  • 0.300mm Max depth (from 0.390)
Cheek volume week 4 3D scan
Week 4
Cheek volume week 12 3D scan
Week 12

Cheek volume, visibly restored.

3D volumetric mapping (subject S002) at Week 12 revealed +2.694 cc of restored volume in the malar / mid-cheek region versus Baseline — consistent with a tissue-plumping effect from the SenoP3™ formulation.

  • +2.694cc Mid-cheek volume gain Week 12
  • Malar Mid-cheek region mapped
  • 3D PRIMOS volumetric scan

Source: Nuvane SenoP3™ IRB-approved Clinical Study (submitted to publication): 3D PRIMOS surface topography & volumetric mapping at Baseline, Week 4 and Week 12.

The SenoP3™ Complex

Three peptides, three jobs, one synergy.

SenoP3™ is a triple-peptide complex. Each peptide speaks the skin’s own biochemical language — signalling cells to rebuild, defend and relax — and together they act across structure, resilience and expression.

THE SCIENCE INSIDE

What Makes
SenoP3™
Work

  • Copper Tripeptide-1 Boosts collagen, elastin, and hyaluronic acid to visibly smooth wrinkles and improve skin texture. Clinically shown to reduce wrinkle depth by 45% and increase elasticity over 12 months.
  • Acetyl Hexapeptide-8 A powerhouse antioxidant that supports skin repair and regeneration. Increases skin density by 33% while enhancing resilience and firmness.
  • Palmitoyl Tripeptide-38 Also known as Argireline, this peptide helps relax facial tension to visibly soften expression lines. Shown to reduce crow's feet by 48% and forehead lines by 47% in just 28 days.

Clinical results of
SenoP3™
peptides

Clinical trials have proven the efficacy of signal peptides in improving skin appearance. Argireline decreased crow's feet by 48% and forehead lines by 47% in just 28 days.1 Palmitoyl Tripeptide-38 reduced wrinkle depth by 45% and increased elasticity by 18.5% within two months.2 Copper Tripeptide-1 improved skin density by 35% and reduced fine lines by 27% after 12 weeks.3
1. Wang, Y., et al. (2013). Am. J. Clin. Dermatol., 14(2), 147-153. 2. Schagen, S. K. (2017). Cosmetics, 4(2), 16. 3. Leyden, J. J., et al. (2002). Amer. Acad. Dermatol. 60th Ann. Mtg.
0%+ Acetyl Hexapeptide-8 decreased crow's feet & forehead lines.
Acetyl Hexapeptide-8 clinical results chart
0%+ Copper Tripeptide-1 improved skin density and reduced fine lines.
Copper Tripeptide-1 clinical results chart

Clinical results of Nuvane skin hydration

Corneometer measurements demonstrated significant increases in skin hydration from baseline at both week 4 (mean change +7.60 AU, +14.6%) and week 12 (mean change +8.92 AU, +17.1%), with 81.6% and 84.2% of subjects showing improvement, respectively.
AU = arbitrary units. All results p<0.001.
Source: Nuvane SenoP3™ IRB-approved Clinical Study (submitted to publication).
0%+ Noticed significant skin hydration improvements by week 12
Skin hydration improvements by week 12 chart
0%+ Skin hydration increase — visible in as little as 4 weeks, measured by Corneometer CM 825.
Skin hydration increase chart

Every active earns its place

Nuvane combines biomimetic peptides with evidence-backed actives and marine botanicals, each chosen for a documented mechanism, not a trend.

Key Longevity Actives

  • Pure Retinol

    Accelerates renewal, softens fine lines

  • Bakuchiol

    Gentle retinol alternative; smooths & firms

  • THD Vitamin C

    Brightens & protects with daily antioxidant defence

  • Hyaluronic Acid

    Deeply hydrates for plumper texture

  • Copper Peptides

    Support repair & stronger-looking skin

  • Niacinamide

    Balances tone & reinforces the barrier

  • Barrier Ceramide

    Strengthens barrier; locks in moisture

  • Caffeine

    Refreshes tired eyes; reduces puffiness

Subject Self-Assessment • Week 12

What the data measured, subjects could feel.

In the same 12-week study, subjects rated their own visible and tactile results.

0% Overall satisfaction
0% Overall improvement
0% Skin smoothness
0% Better than other anti-aging treatments
0% Reduction in fine lines
0% Brightness & radiance

Based on subject self-assessment at Week 12 (n=38 per-protocol). Results expressed as % favourable response.

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  • Get your personalized
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